Hyunsook Park, PhD
Assistant Professor
Dept of Biological Sciences



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                                                                                                           E-mail address: hpark8@calstatela.edu

                                                                                                  Office Hour : Please contact the department office (BS143) to schedule               

                                                                                                                                                          an appointment   


BACKGROUND

Dr.Park received her Ph.D. Microbiology from Ewha Womans University (Seoul, Korea)  in 2002, followed by postdoctoral training in mycology and molecular biology at the Division of Infectious Diseases, Harbor-UCLA Medical Center.  Dr. Park joined the Department of Biological Sciences at Cal State LA in 2008.



TEACHING INTERESTS

Dr. Park currently teaches lecture courses in General Microbiology, Molecular Genetics and Fungal pathogenesis. She also teaches lab courses in Genearal Microbiology, Clinical Microbiology,  and Pathogenic Bacteria. In addition, she provides research training to the students in the Department of Biological Sciences.


LECTURE MATERIALS

The lecture contents will be found on Moodle 



RESEARCH
 

     Our research focuses on host-pathogen interactions in infectious disease.  In particular,  we have focused on the pathogenic mechanisms of     
the opportunisitic human pa
thogenic fungus, Candida albicansCandida albicans causes variety of infection with significant morbidity and mortality in a large, diverse population of immunocompromised patients. This suggests that C. albicans possesses unique characteristics that enable it to colonize in the host and cause disease when the host has immune deficiency. Interestingly, C. albicans interacts with oral epithelial cells during oropharyngeal candidiasis and with vascular endothelial cells when it disseminates hematogenously. Particularly, the ability of C. albicans to adhere, invade and injure human endothelial cells and oral epithelial cells is believed as a critical step to establish the infection. Our previous work has demonstrated that some C. albicans mutants with reduced ability to injure oral epithelial cells in vitro have also attenuated virulence in the mouse model of oropharyngeal candidiasis.  Therefore, the in vitro epithelial cell interaction model is a great screening tool to identify mutants with virulence defects. Our research has focused on three different categories; (1) C. albicans virulence factors that play key role in host-pathogen interaction, (2) Key regulators (especially singaling cascaed) governing C. albicans virulence, (3) C. albicans response to antimicrobial peptides.


Date   Recent Publications
2012Phan QT, Eng DK, Mostowy S, Park H, Cossart P, and Filler SG. Role of Endothelial Cell Septin 7 in the Endocytosis of Candida albicans. J. Cell Sci.
2009Park H, Liu Y, Solis N, Spotkov J, Hamaker J, Blankenship JR, Yeaman MR, Mitchell AP, Liu H and Filler SG. Transcriptional responses of Candida albicans to epithelial and endothelial cells. Eukaryotic Cell 8:1498-1510
2008Gank KD, Yeaman MR, Kojima S, Yount NY, Park H, Edwards, Jr. JE, Filler SG, and Fu Y. SSD1 is Integral to Host Defense Peptide Resistance in Candida albicans. Eukaryot Cell 7(8):1318-1327
2008Barker KS, Park H, Phan QT, Xu L, Homayouni R, Rogers PD, Filler SG. Transcriptome Profile of the Vascular Endothelial Cell Response to Candida albicans. J. Infect Dis. 198:193–202 (contributed equally)
2008 Goyard S, Knechtle P, Chauvel M, Mallet A, Prévost MC, Proux C, Coppée JY, Schwartz P, Dromer F, Park H, Filler SG, Janbon G, d'Enfert C.  The Yak1 Kinase is Involved in the Initiation and Maintenance of Hyphal Growth in Candida albicans. Mol Biol Cell.19(5), 2251-2266
2007 Thewes S, Kretschmar M, Park H, Schaller M, Filler SG, Hube B.  In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion.    Mol Microbiol. 2007 Mar;63(6):1606-28.
2006
Martinez-Lopez R, Park H, Myers CL, Gil C, Filler SG. Candida albicans Ecm33p is important for normal cell wall architecture and interactions with host cells. Eukaryot Cell. 2006 Jan;5(1):140-7
2005
Park H, Myers CL, Sheppard DC, Phan QT, Sanchez AA, E Edwards J, Filler SG. Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis. Cell Microbiol. 2005 Apr;7(4):499-510. 
2003

Choi S, Park N, Park H, Park M, Woo J, Choi W  Interacting domain between yeast chitin synthase 3 and chitin synthase 4 is involved in angiogenesis of chitin ring, but not for cell wall chitin.  J Microbiol Biotechnol 13:263-268  
2002 Park H, Choi S, Park N, Kim C, Kim S, Choi W  Identification of a domain in yeast chitin synthase 3 interacting with chitin synthase 4 by two hybrid analysis.  J Microbiol Biotechnol 12:943-949
2002 Kim M, Park H, C Kim, Park H, Choi W  Inhibition of chitin synthases by nikkomycin is dependent on media composition in Candida albicans.  Yeast 19:341-349.
2001 Min J, Lee Y, Kim Y, Park H, Han S, Jhon G-J, Choi W  Lysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase activity.  Biochim Biophysica Acta 1531:77-89.
1998 Park H, Jhon G-J, Choi W  Hyphal growth inhibition by deer antler extract mimics the effect of chitin synthase deletion in Candida albicans.  J Microbiol Biotechnol 8:422-425
1998 Park H, John G-J, Choi W  1998 Deer antler extract selectively suppresses hyphal growth in dimorphic fungus, Candida albicans.  J Microbiol Biotechnol 8:291-294

  EDUCATIONAL BACKGROUND

Ph.D. Microbiology (emphasis in mycology and molecular biology) 2002
Ewha Womans University, Seoul, Korea

M.S. Microbiology
1998
Ewha Womans University, Seoul, Korea

B.S. Biology
(Minor: Science Education) 1996
Ewha Womans University, Seoul, Korea