#### Valentino Crespi, Ph.D. - January 27, 2010

California State University, Los Angeles

Department of Computer Science

"Trackability and Machine Learning of Behaviors and Processes"

In this talk I will start by introducing an original and rigorous concept of "trackability" of processes in a distributed sensing system. The purpose of this notion of trackability is to determine the "complexity" of estimating state trajectories of a target process based on a discrete-time sequence of noisy "observations". Then I will present new algorithms to learn Hidden Markov Models (HMMs) from typical realizations of the associated stochastic process. Those methods are based on the non-negative matrix factorization (NMF) of higher order Markovian statistics and are structurally different from the classical Baum-Welsh and associated approaches.

#### Lisette De Pillis, Ph.D. - February 10, 2010

Harvey Mudd College

Department of Mathematics

"Mathematical Modeling of Cancer Growth and Immunological Indirection"

Abstract: Immunotherapy, a treatment approach that enhances the body's

natural ability to fight cancers, is becoming increasingly prevalent in

many multi-stage treatment programs that also include chemotherapy,

radiation and surgery. The critical importance of the immune system

in combating cancer has been verified both clinically and through mathematical

models. In this talk, we will discuss the biological and mathematical

sides of the question of how cancer grows, how the cancer interacts

with the immune system, and treatment approaches that harness the

power of the immune system.

#### Christof Koch, Ph.D. - March 10, 2010

California Institute of Technology

Professor of Cognitive and Behavioral Biology and

Professor of Computation and Neural Systems

“The Science of Consciousness: What do we Know and What do we Need to Know?”

Abstract: At the beginning of the third millennium, a Science of Consciousness is beginning to emerge that seeks to understand how subjective conscious sensations, qualia, emerge from certain types of organized matter, in particular from the mammalian cortico-thalamic system. I will summarize what is known about the neurobiology of consciousness, outline the limits to our knowledge, and describe ongoing psychophysical and electrophysiological experiments to manipulate the relationship between physical stimuli and their associated conscious percepts and to discover and characterize the neuronal correlates of consciousness (NCC). I will conclude by discussing a very promising theoretical approach to consciousness - Integrated Information Theory by Tononi - grounded in circuit complexity and information theory.

Seminars are from 3:00-4:00 p.m. in Biological Sciences room 244

Download the Winter 2010 Seminar Series flyer!