obHLH transcription factor
oHomodimer or heterodimer with other bHLH proteins (i.e. E proteins)
oRegulates cell movement and mesoderm development during early embryogenesis (i.e. bone and muscle)
oTwist-1 has both positive and negative functions regulating mesenchymal cell differentiation
oBinds to a conserved E-box sequence (CANNTG) on the promoter region that activates or inhibits transcription of a target gene